Several North American schools of public health and medicine have launched training partnerships with institutions in low- and middle-income countries. These include important “twinning” opportunities between North American institutions and sister schools in sub-Saharan Africa. Through the Fogarty International Center, the U.S. National Institutes of Health has just announced a Medical Education Partnership Initiative (MEPI) with the President’s Emergency Program for AIDS Relief (PEPFAR) to further support such U.S. and African training partnerships , which will also offer enormous potential for capacity-building in the region. At the same time, I believe there remains a strong need to have a centralized facility in North America for training in tropical medicine, i.e., one that embraces whole-organism biology of key NTD pathogens, new and appropriate health technologies and their introduction into global public health practice, and clinical tropical medicine. A National School of Tropical Medicine or the equivalent based in North America would address an important gap in training in the region.