Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice

Here we developed a suitable platform for the large scale production ofrecombinant Tc24 (rTc24) and show that when rTc24 is combined with a monophosphoryl-lipid A (MPLA) adjuvant, the formulatedvaccine induces a Th1-biased immune response in mice . . . Abstract here: 

http://www.ncbi.nlm.nih.gov/pubmed/?term=.++Expression%2C+purification%2C+immunogenicity%2C+and+protective+efficacy+of+a+recombinant+Tc24+antigen+as+a+vaccine+against+Trypanosoma+cruzi+infection+in+mice.

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