Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults

Vaccination of both hookworm-naïve and hookworm-exposed adults with recombinant Na-GST-1 was safe, well tolerated, and resulted in significant antigen-specific IgG responses. Based on these results, this vaccine will be advanced into clinical trials in children and eventual efficacy studies. Read it here:

http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005574

 

Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine

. . .the achievements and obstacles encountered during process development as well as characterization and stability of the purified Na-APR-1 (M74) protein and formulated vaccine. The expression, purification and analysis of purified Na-APR-1 (M74) protein obtained from representative 5 kg reproducibility runs is also presented. Open access:

http://www.tandfonline.com/doi/full/10.1080/21645515.2015.1036207#abstract