Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults

Vaccination of both hookworm-naïve and hookworm-exposed adults with recombinant Na-GST-1 was safe, well tolerated, and resulted in significant antigen-specific IgG responses. Based on these results, this vaccine will be advanced into clinical trials in children and eventual efficacy studies. Read it here:

http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005574

 

Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine

. . .the achievements and obstacles encountered during process development as well as characterization and stability of the purified Na-APR-1 (M74) protein and formulated vaccine. The expression, purification and analysis of purified Na-APR-1 (M74) protein obtained from representative 5 kg reproducibility runs is also presented. Open access:

http://www.tandfonline.com/doi/full/10.1080/21645515.2015.1036207#abstract

Worms

New published information reveals that intestinal worm infections rank among the most common afflictions of people living in extreme poverty. The numbers are quite astonishing. More than 800 million people are currently believed to harbor Ascaris roundworms in their gastrointestinal tract, while around 450 million people are infected with either hookworms or Trichuris whipworms. Frequently a single individual, especially a child, is simultaneously infected with two or three of these types of intestinal worms at the same time, so that the term “unholy trinity” has been used to describe them.

Read the rest here